The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Sep. 28, 2005
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Hinrich Wilhelm Helmut Göhlmann, ′s-Hertogenbosch, NL;
Jean-marc Edmond Fernand Marie Neefs, Lier, BE;
Peter Karel Maria Verhasselt, Herent, BE;
Johann Winkler, Brasschaat, BE;
Marc René DE Jonge, Tilburg, NL;
Lucien Maria Henricus Koymans, Retie, BE;
Koenraad Jozef Lodewijk Marcel Andries, Beerse, BE;
Hinrich Wilhelm Helmut Göhlmann, ′s-Hertogenbosch, NL;
Jean-Marc Edmond Fernand Marie Neefs, Lier, BE;
Peter Karel Maria Verhasselt, Herent, BE;
Johann Winkler, Brasschaat, BE;
Marc René De Jonge, Tilburg, NL;
Lucien Maria Henricus Koymans, Retie, BE;
Janssen Pharmaceutica N.V., Beerse, BG;
Abstract
This invention provides an isolated mutant atpE protein and departing from said mutant atpE protein the identification of an ATPase binding domain. This invention also provides related nucleic acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with an atpE protein, i.e. with the ATPase binding domain of the present invention, as well as pharmaceuticals compositions comprising said test compound, in particular as antimicrobials, more particular as antimycobacterial agent, even more particular for treating tuberculosis in a subject.