The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Sep. 29, 2008
Sek Chung Fung, Gaithersburg, MD (US);
Matthew Moyle, Redmond, WA (US);
Mason LU, Houston, TX (US);
Changning Yan, Houston, TX (US);
Sanjaya Singh, Sandy Hook, CT (US);
Dan Huang, Short Hills, NJ (US);
Sek Chung Fung, Gaithersburg, MD (US);
Matthew Moyle, Redmond, WA (US);
Mason Lu, Houston, TX (US);
Changning Yan, Houston, TX (US);
Sanjaya Singh, Sandy Hook, CT (US);
Dan Huang, Short Hills, NJ (US);
Genentech, Inc., South San Francisco, CA (US);
Abstract
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.