The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 2012
Filed:
Mar. 05, 2010
Bennett L. Ibey, College Station, TX (US);
Vamsi K. Yadavalli, North Bethesda, MD (US);
Rebecca M. Rounds, College Station, TX (US);
Hope T. Beier, College Station, TX (US);
Gerard L. Cote, College Station, TX (US);
Michael V. Pishko, State College, PA (US);
Bennett L. Ibey, College Station, TX (US);
Vamsi K. Yadavalli, North Bethesda, MD (US);
Rebecca M. Rounds, College Station, TX (US);
Hope T. Beier, College Station, TX (US);
Gerard L. Cote, College Station, TX (US);
Michael V. Pishko, State College, PA (US);
The Texas A&M University System, College Station, TX (US);
Abstract
This disclosure relates to a method of measuring a glucose concentration metric or a glucose metric in a patient by contacting an implantable glucose-sensing device with a test sample, which may be in the patient, under conditions that permit a sugar-binding molecule and a functionalized polymer or nano-particle ligand present throughout the matrix of a hydrogel to interact in a glucose-dependent manner to produce an optical signal resulting from quenching of a first fluorophore linked to the ligand or sugar-binding molecule and having a fluorescent emission spectrum quenched upon binding or release of glucose. Next the first fluorophore may be excited with light of a certain wavelength. Then at least one wavelength of light in the glucose-dependent optical signal from the fluorophore may be detected with a detector to produce a detected light signal, which may be processed to produce a glucose metric, such as a glucose concentration metric.