The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2011
Filed:
Mar. 29, 2007
Masaki Okamoto, Osaka, JP;
Akira Sakuragi, Osaka, JP;
Yoshikazu Mori, Osaka, JP;
Takeshi Hamada, Osaka, JP;
Hitoshi Kubota, Osaka, JP;
Yoshinori Nakamura, Osaka, JP;
Takanori Higashijima, Osaka, JP;
Norimitsu Hayashi, Osaka, JP;
Masaki Okamoto, Osaka, JP;
Akira Sakuragi, Osaka, JP;
Yoshikazu Mori, Osaka, JP;
Takeshi Hamada, Osaka, JP;
Hitoshi Kubota, Osaka, JP;
Yoshinori Nakamura, Osaka, JP;
Takanori Higashijima, Osaka, JP;
Norimitsu Hayashi, Osaka, JP;
Mitsubishi Tanabe Pharma Corporation, Osaka, JP;
Abstract
The present invention is to provide a process for preparing optically active tetrahydroquinoline derivatives which can be used for the treatment and/or prevention of diseases such as arteriosclerotic diseases, dyslipidemia and the like, and a process for preparing synthetic intermediates thereof. Specifically, (2R,4S)-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinolin-4-ylamine or a salt thereof is prepared with fewer steps without using an optical resolution, and the optically active tetrahydroquinoline derivatives are obtained from the amine compound.