The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 27, 2011

Filed:

Jan. 07, 2010
Applicants:

Gerald R. Crabtree, Woodside, CA (US);

Peter Belshaw, Somerville, MA (US);

Stuart L. Schreiber, Boston, MA (US);

David M. Spencer, Houston, TX (US);

Thomas J. Wandless, Palo Alto, CA (US);

Inventors:

Gerald R. Crabtree, Woodside, CA (US);

Peter Belshaw, Somerville, MA (US);

Stuart L. Schreiber, Boston, MA (US);

David M. Spencer, Houston, TX (US);

Thomas J. Wandless, Palo Alto, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
Abstract

We have developed a general procedure for the regulated (inducible) dimerization or oligomerization of intracellular proteins and disclose methods and materials for using that procedure to regulatably initiate cell-specific apoptosis (programmed cell death) in genetically engineered cells.


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