The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2011
Filed:
Apr. 11, 2008
Takumi Kawabe, Numazu, JP;
Machiyo Ishigaki, Numazu, JP;
Takuji Sato, Numazu, JP;
Sayaka Yamamoto, Numazu, JP;
Yoko Hasegawa, Numazu, JP;
Takumi Kawabe, Numazu, JP;
Machiyo Ishigaki, Numazu, JP;
Takuji Sato, Numazu, JP;
Sayaka Yamamoto, Numazu, JP;
Yoko Hasegawa, Numazu, JP;
Canbas Co., Ltd., Shizuoka, JP;
Abstract
Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.