The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2011
Filed:
Apr. 10, 2008
Jose R. Conejo-garcia, East Thetford, VT (US);
Eduardo Huarte-sobrino, Bozeman, MT (US);
Juan Cubillos-ruiz, Lebanon, NH (US);
Yolanda Nesbeth, Lebanon, NH (US);
Diana G. Martinez, White River Junction, VT (US);
Jose R. Conejo-Garcia, East Thetford, VT (US);
Eduardo Huarte-Sobrino, Bozeman, MT (US);
Juan Cubillos-Ruiz, Lebanon, NH (US);
Yolanda Nesbeth, Lebanon, NH (US);
Diana G. Martinez, White River Junction, VT (US);
Trustees of Dartmouth College, Hanover, NH (US);
Abstract
The invention relates to a CD161 ligand known as Proliferation-Induced Lymphocyte-Associated Receptor (PILAR), which is crucial for a robust expansion of human lymphocytes. PILAR is markedly up-regulated on both CD4 and CD8 T cells upon TCR engagement and increases the expression of anti-apoptotic genes and glucose transporters through CD161, which globally results in a dramatic enhancement of T cell proliferation. Agents which stimulate or block this activity are also provided as are methods for manipulating PILAR signaling in the treatment of disease.