The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2011
Filed:
Jul. 08, 2008
Amy H. Yin, San Jose, CA (US);
Sheri Miraglia, Alameda, CA (US);
Wayne G. Godfrey, Atherton, CA (US);
David W. Buck, Half Moon Bay, CA (US);
Amy H. Yin, San Jose, CA (US);
Sheri Miraglia, Alameda, CA (US);
Wayne G. Godfrey, Atherton, CA (US);
David W. Buck, Half Moon Bay, CA (US);
Amcell Corporation, Burlingame, CA (US);
Abstract
Compositions comprising a cell expressing an AC133 cell surface antigen and an antibody, or antigen binding fragment thereof, that specifically binds to the antigen are provided. Expression of the antigen is highly tissue specific. It is detected on a subset of hematopoietic progenitor and stem cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34and contains substantially all of the CFU-GM activity present in the CD34population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen can be further purified by selection for other hematopoietic stem cell and progenitor cell markers.