The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 20, 2011

Filed:

Feb. 19, 2010
Applicants:

Kevin D. Shenk, Palo Alto, CA (US);

Francesco Parlati, San Francisco, CA (US);

Han-jie Zhou, Foster City, CA (US);

Catherine Sylvain, San Mateo, CA (US);

Mark S. Smyth, San Mateo, CA (US);

Mark K. Bennett, Moraga, CA (US);

Guy J. Laidig, Menlo Park, CA (US);

Inventors:

Kevin D. Shenk, Palo Alto, CA (US);

Francesco Parlati, San Francisco, CA (US);

Han-Jie Zhou, Foster City, CA (US);

Catherine Sylvain, San Mateo, CA (US);

Mark S. Smyth, San Mateo, CA (US);

Mark K. Bennett, Moraga, CA (US);

Guy J. Laidig, Menlo Park, CA (US);

Assignee:

Onyx Therapeutics, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/404 (2006.01); A61K 31/381 (2006.01); A61K 31/336 (2006.01); C07D 209/04 (2006.01); C07D 333/52 (2006.01); C07D 303/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

One aspect of the invention relates to inhibitors that preferentially inhibit immunoproteasome activity over constitutive proteasome activity. In certain embodiments, the invention relates to the treatment of immune related diseases, comprising administering a compound of the invention. In certain embodiments, the invention relates to the treatment of cancer, comprising administering a compound of the invention.


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