The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2011
Filed:
Nov. 13, 2007
Lawrence J. Delucas, Birmingham, AL (US);
Wilbur W. Wilson, Starkville, MS (US);
Lisa Nagy, Birmingham, AL (US);
David Johnson, Birmingham, AL (US);
Charles S. Henry, Fort Collins, CO (US);
Lawrence J. DeLucas, Birmingham, AL (US);
Wilbur W. Wilson, Starkville, MS (US);
Lisa Nagy, Birmingham, AL (US);
David Johnson, Birmingham, AL (US);
Charles S. Henry, Fort Collins, CO (US);
The UAB Research Foundation, Birmingham, AL (US);
Mississippi State University, Mississippi State, MS (US);
Colorado State University Research Foundation, Fort Collins, CO (US);
Abstract
The present disclosure provides a method to allow a user to pre-screen numerous crystallization conditions in the crystallization space to identify those conditions with the highest probability of yielding crystals and high quality diffracting crystals. In one embodiment, the dilute solution thermodynamic virial coefficient, termed B, is used to aid in the determination crystallization conditions that increase the probability of producing crystals for the crystallant of interest. The present disclosure also provide methods for predicting solution conditions that generate beneficial solubility and/or stability conditions for a polypeptide of interest using the B parameter. Devices for use in the described methods are also described.