The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 20, 2011
Filed:
Feb. 13, 2009
Kathleen Anne Derwin, Shaker Heights, OH (US);
Joseph Patrick Iannotti, Strongsville, OH (US);
Likang Chin, Cleveland, OH (US);
Anthony Calabro, Cleveland Heights, OH (US);
Kathleen Anne Derwin, Shaker Heights, OH (US);
Joseph Patrick Iannotti, Strongsville, OH (US);
LiKang Chin, Cleveland, OH (US);
Anthony Calabro, Cleveland Heights, OH (US);
The Cleveland Clinic Foundation, Cleveland, OH (US);
Abstract
A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.