The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Dec. 18, 2008
Elena Barbanti, Cologno Monzese, IT;
Carla Caccia, Cardano Al Campo, IT;
Patricia Salvati, Arese, IT;
Francesco Velardi, Cameri, IT;
Tiziano Ruffilli, Vigliano Biellese, IT;
Luigi Bogogna, Vaprio D'Agogna, IT;
Elena Barbanti, Cologno Monzese, IT;
Carla Caccia, Cardano Al Campo, IT;
Patricia Salvati, Arese, IT;
Francesco Velardi, Cameri, IT;
Tiziano Ruffilli, Vigliano Biellese, IT;
Luigi Bogogna, Vaprio D'Agogna, IT;
Newron Pharmaceuticals S.p.A., Bresso, IT;
Abstract
A process for obtaining therapeutically active 2-[4-(3- and 2-(fluorobenzyloxy)benzylamino]propanamides and their salts with pharmaceutically acceptable acids with high purity degree, in particular, with a content of dibenzyl derivatives impurities lower than 0.03%, preferably lower than 0.01% by weight. The process is carried out by submitting the Schiff bases intermediates 2-[4-(3- and 2-fluorobenzyloxy)benzylideneamino]propanamides to catalytic hydrogenation in the presence of a heterogeneous catalyst in a protic organic solvent.