The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Aug. 13, 2009
Show-wen Liu, Shetou Township, Changhua County, TW;
Cheng-hsien Lin, Taipei, TW;
Tsyh-lang Lin, Bade, TW;
Cheng-fang Hsu, Toufen Township, Miaoli County, TW;
Show-Wen Liu, Shetou Township, Changhua County, TW;
Cheng-Hsien Lin, Taipei, TW;
Tsyh-Lang Lin, Bade, TW;
Cheng-Fang Hsu, Toufen Township, Miaoli County, TW;
Atomic Energy Council-Institute of Nuclear Energy Research, Taoyuan County, TW;
Abstract
A method for preparing a precursor of radioactive 3-iodobenzylguanidine- N,N'-bis(tert-butyloxycarbonyl)-3-(tri-n-butyltin)benzylguanidine) (MSnBG) is revealed. The method includes following steps. Firstly, obtain 3-iodobenzylguanidine bicarbonate by an addition reaction between 3-iodobenzylamine hydrochloride and cyanamide. Use di-tert-butyl dicarbonate as a protecting agent for NH group and convert 3-iodobenzylguanidine bicarbonate into N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine. At last, under catalysis of bis(triphenylphosphine) palladium dichloride, obtain a final product MSnBG by a substitution reaction between N,N′-bis(tert-butyloxycarbonyl)-N-(3-iodobenzyl) guanidine and bis(tri-n-butyltin). MSnBG is used in no-carrier-added synthesis of [*l]MIBG.