The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Oct. 09, 2007
Srinivas Laxminarayan Pathi, Karnataka, IN;
Ravikumar Puppala, Banaswadi, IN;
Rajendra Narayanrao Kankan, Mumbai, IN;
Dharmaraj Ramachandra Rao, Mumbai, IN;
Srinivas Laxminarayan Pathi, Karnataka, IN;
Ravikumar Puppala, Banaswadi, IN;
Rajendra Narayanrao Kankan, Mumbai, IN;
Dharmaraj Ramachandra Rao, Mumbai, IN;
Cipla Limited, Mumbai, IN;
Abstract
A process for the preparation of trityl olmesartan comprising (a) condensing 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazol-5-carboxylic acid alkyl ester with trityl biphenyl bromide in the presence of a polar aprotic solvent and a base selected from the group consisting of alkali metal carbonates, alkali metal hydroxides, alkali metal alkoxides, and tertiary amines to obtain a compound of formula V, b) deesterifying the compound of formula (V) with a base; and c) reacting the product of step (b) with 4-halomethyl-5-methyl-2-oxo-1,3-dioxolene of formula (IV), wherein X is halogen selected from F or Cl or Br or I, to obtain trityl olmesartan medoxomil of formula. The trityl olmesartan medoxomil may be deprotected to produce olmesartan medoxomil.