The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Aug. 07, 2006
Hiroyoshi Yamada, Tokyo, JP;
Hirotsune Itahana, Tokyo, JP;
Ayako Moritomo, Tokyo, JP;
Takaho Matsuzawa, Tokyo, JP;
Eisuke Nozawa, Tokyo, JP;
Shinobu Akuzawa, Tokyo, JP;
Koichiro Harada, Okayama, JP;
Hiroyoshi Yamada, Tokyo, JP;
Hirotsune Itahana, Tokyo, JP;
Ayako Moritomo, Tokyo, JP;
Takaho Matsuzawa, Tokyo, JP;
Eisuke Nozawa, Tokyo, JP;
Shinobu Akuzawa, Tokyo, JP;
Koichiro Harada, Okayama, JP;
Astellas Pharma Inc., Tokyo, JP;
Abstract
[Problem] To provide a compound which can be used in the prevention and/or treatment of diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly in the treatment of irritable bowel syndrome (IBS) and/or prevention of migraine. [Means for Resolution] It was found that an acylguanidine derivative having a tricyclic structure or a pharmaceutically acceptable salt thereof has a strong antagonism to 5-HTreceptor and 5-HTreceptor. In addition, the compound of the present invention having antagonism to both of the receptors showed superior pharmacological action in comparison with the case of the single use of an antagonist selective for either one of the receptors. Based on the above, the compound of the present invention is useful in preventing and/or treating diseases in which 5-HTreceptor and 5-HTreceptor are concerned, particularly in treating irritable bowel syndrome (IBS) and/or preventing migraine.