The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Dec. 13, 2011

Filed:

Jan. 13, 2011
Applicants:

Heiko Kroth, Stadecken-Elsheim, DE;

Tim Feuerstein, Neckargemuend, DE;

Frank Richter, HD-Handschuhsheim, DE;

Jürgen Boer, Wiesbaden, DE;

Michael Essers, Bergisch Gladbach, DE;

Bert Nolte, Aachen, DE;

Matthias Schneider, Dossenheim, DE;

Matthias Hochgürtel, Schriesheim, DE;

Fritz-frieder Frickel, Deidensheim, DE;

Arthur G. Taveras, Southborough, MA (US);

Christoph Steeneck, Dossenheim, DE;

Inventors:

Heiko Kroth, Stadecken-Elsheim, DE;

Tim Feuerstein, Neckargemuend, DE;

Frank Richter, HD-Handschuhsheim, DE;

Jürgen Boer, Wiesbaden, DE;

Michael Essers, Bergisch Gladbach, DE;

Bert Nolte, Aachen, DE;

Matthias Schneider, Dossenheim, DE;

Matthias Hochgürtel, Schriesheim, DE;

Fritz-Frieder Frickel, Deidensheim, DE;

Arthur G. Taveras, Southborough, MA (US);

Christoph Steeneck, Dossenheim, DE;

Assignee:

Amgen Inc., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/41 (2006.01); A61K 31/40 (2006.01); C07D 257/02 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates generally to pyrrolidine and thiazolidine DPP-IV inhibitor compounds. The present invention also provides synthetic methods for preparation of such compounds, methods of inhibiting DPP-IV using such compounds and pharmaceutical formulations containing them for treatment of DPP-IV mediated diseases, in particular, Type-2 diabetes.


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