The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Dec. 17, 2004
Applicants:
Simon L. Stubbs, Cardiff, GB;
Michael J. Francis, Cardiff, GB;
Adrian Cushing, Cardiff, GB;
Rahman A. Ismail, Cardiff, GB;
Inventors:
Simon L. Stubbs, Cardiff, GB;
Michael J. Francis, Cardiff, GB;
Adrian Cushing, Cardiff, GB;
Rahman A. Ismail, Cardiff, GB;
Assignee:
GE Healthcare UK Limited, Little Chalfont, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); C12N 15/00 (2006.01); C12N 1/20 (2006.01); C07K 1/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to a cytochrome c-reporter fusion protein construct comprising a modified cytochrome c protein which targets the mitochondria and has a reduced ability to induce apoptosis in a living cell. The invention also relates to nucleic acid constructs encoding such protein fusions and cells stably transfected with such constructs. The stably transfected cells of the invention can be used in assays to detect apoptosis.