The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Mar. 30, 2010
Daniel H. Fowler, Bethesda, MD (US);
Unsu Jung, Ashburn, VA (US);
Ronald E. Gress, Gaithersburg, MD (US);
Bruce Levine, Cherry Hill, NJ (US);
Carl June, Merion Station, PA (US);
Daniel H. Fowler, Bethesda, MD (US);
Unsu Jung, Ashburn, VA (US);
Ronald E. Gress, Gaithersburg, MD (US);
Bruce Levine, Cherry Hill, NJ (US);
Carl June, Merion Station, PA (US);
The United States of America as represented by the Secretary of the Deparment of Health and Human Services, Washington, DC (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Abstract
Methods for generating highly enriched Th1/Tc1 and Th2/Tc2 functions are described. In particular, the generation of these functions are attained by the addition of an immune suppression drug, rapamycin or a rapamycin derivative compound. In addition to enhanced purity of T cell function, the T cells generated in rapamycin also express molecules that improve immune T cell function such as CD28 and CD62L. Such rapamycin generated functional T cell subsets may have application in the prevention or treatment of GVHD after allogeneic hematopoietic stem cell transplantation, the treatment of autoimmunity, or the therapy of infection or cancer.