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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8075917 B1

PDFFull Text
Date of Patent:
Dec. 13, 2011

Filed:

Jul. 18, 2003

Composition for solubilization of paclitaxel and preparation method thereof

Applicants:

Hesson Chung, Incheon, KR;

Seo-young Jeong, Gyeonggi-Do, KR;

Ick-chan Kwon, Seoul, KR;

Yeong-taek Park, Gyeonggi-Do, KR;

In-hyun Lee, Seoul, KR;

Soon-hong Yuk, Daejeon, KR;

Young-wook Choi, Seoul, KR;

Jae-hyung Park, Seoul, KR;

Jin-wook Chung, Seoul, KR;

Inventors:

Hesson Chung, Incheon, KR;

Seo-Young Jeong, Gyeonggi-Do, KR;

Ick-Chan Kwon, Seoul, KR;

Yeong-Taek Park, Gyeonggi-Do, KR;

In-Hyun Lee, Seoul, KR;

Soon-Hong Yuk, Daejeon, KR;

Young-Wook Choi, Seoul, KR;

Jae-Hyung Park, Seoul, KR;

Jin-Wook Chung, Seoul, KR;

Assignee:

Daehwa Pharm. Co., Ltd., Gangwon-Do, KR;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Robert A Wax

Assistant Examiner:

Jeffrey T Palenik

Int. Cl.
CPC ...
A61K 7/00 (2006.01); A61K 8/02 (2006.01); A61K 9/14 (2006.01); A61K 47/00 (2006.01); A61K 31/04 (2006.01); A61K 31/15 (2006.01); A01N 25/00 (2006.01); A01N 33/18 (2006.01); A01N 33/24 (2006.01); A01N 27/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one oil and 0.01 to 20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4 to 90% by weight of at least one selected from the monoglycerides, 0.01 to 90% by weight of at least one emulsifier and 0.01 to 20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

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