The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 13, 2011
Filed:
Oct. 15, 2009
Gireesh Rajashekara, Madison, WI (US);
Gary Splitter, Brooklyn, WI (US);
Gireesh Rajashekara, Madison, WI (US);
Gary Splitter, Brooklyn, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Certain attenuated mutants of, especiallyand, when administered to a human or animal trigger a protective immune response such that subsequent challenge with virulentof the same species does not result in disease or results in much less severe symptoms. Functional inactivation of galE, a virB gene or the operon (ORFs 1087-1090) comprising the gene encoding β-hexosaminidase (BMEI1087) and a lytic murein transglycosylase gene (BMEI1088). A specific example of the attenuated galE mutant which produces a protective immune response isGR024. The specific example of an inactivated ORF1087-1090 operon isGR026; it has an insertion mutation in the promoter region upstream of ORF 1090. Vaccination with live cells of either or both of these mutants results in a T cell response which protects the human or animal against challenge with virulent. Similar strategies for protective immunity using live attenuated mutants are useful forandas well.