The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Jun. 06, 2006
Nand Baindur, Kendall Park, NJ (US);
Michael David Gaul, Yardley, PA (US);
Kevin Douglas Kreutter, Plainsboro, NJ (US);
Christian Andrew Baumann, Exton, PA (US);
Alexander J. Kim, Levittown, PA (US);
Guozhang Xu, Bensalem, PA (US);
Robert W. Tuman, Chalfont, PA (US);
Dana L. Johnson, Upper Black Eddy, PA (US);
Nand Baindur, Kendall Park, NJ (US);
Michael David Gaul, Yardley, PA (US);
Kevin Douglas Kreutter, Plainsboro, NJ (US);
Christian Andrew Baumann, Exton, PA (US);
Alexander J. Kim, Levittown, PA (US);
Guozhang Xu, Bensalem, PA (US);
Robert W. Tuman, Chalfont, PA (US);
Dana L. Johnson, Upper Black Eddy, PA (US);
Janssen Pharmaceutica, N.V., Beerse, BE;
Abstract
The invention is directed to alkylquinoline and alkylquinazoline compounds of Formula I: wherein R, R, R, B, Z, G, Q and X are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of FLT3 and/or c-kit and/or TrkB, the use of such compounds to reduce or inhibit kinase activity of FLT3 and/or c-kit and/or TrkB in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to FLT3 and/or c-kit and/or TrkB. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.