The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Dec. 20, 2007
Omayra Liz Padilla DE Jesus, Clifton Park, NY (US);
Ernest William Kovacs, Albany, NY (US);
Matthias Eberhard Glaser, London, GB;
Erik Arstad, London, GB;
Faisal Ahmed Syud, Clifton Park, NY (US);
Omayra Liz Padilla De Jesus, Clifton Park, NY (US);
Ernest William Kovacs, Albany, NY (US);
Matthias Eberhard Glaser, London, GB;
Erik Arstad, London, GB;
Faisal Ahmed Syud, Clifton Park, NY (US);
General Electric Company, Niskayuna, NY (US);
Abstract
Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.