The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Nov. 30, 2004
Applicants:
Alan Ashworth, London, GB;
Stephen Jackson, Cambridge, GB;
Niall Martin, Cambridge, GB;
Graeme Smith, Cambridge, GB;
Inventors:
Alan Ashworth, London, GB;
Stephen Jackson, Cambridge, GB;
Niall Martin, Cambridge, GB;
Graeme Smith, Cambridge, GB;
Assignees:
The Institute of Cancer Research: Royal Cancer Hospital, London, GB;
Kudos Pharmaceuticals Limited, Cambridge, GB;
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/50 (2006.01); A61K 31/44 (2006.01); A61K 31/415 (2006.01); A61K 31/40 (2006.01); A01N 43/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.