The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Feb. 12, 2010
Applicants:
John M. Mcpherson, Hopkinton, MA (US);
Tim Edmunds, Bolton, MA (US);
Qun Zhou, Ashland, MA (US);
Inventors:
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/08 (2006.01);
U.S. Cl.
CPC ...
Abstract
Methods for producing antibody-based therapeutics with enhanced ADCC activity are disclosed. The enhanced ADCC activity is attributed to oligomannose-type N-glycans on the antibodies and Fc fusion proteins of the invention. Also disclosed are methods of using such antibody-based therapeutics for targeted killing of cells in a mammal, including therapeutic methods of treating cancers, autoimmune diseases and other diseases.