The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Dec. 09, 2005
Shuming Wang, Beijing, CN;
LI Wang, Beijing, CN;
Xiaoling Fan, Beijing, CN;
Huiyong Xue, Beijing, CN;
Shuang Zhang, Beijing, CN;
Enhong Zhang, Beijing, CN;
Xuying Zhong, Beijing, CN;
Yucheng LU, Beijing, CN;
Chun LI, Beijing, CN;
LI Song, Beijing, CN;
Shuming Wang, Beijing, CN;
Li Wang, Beijing, CN;
Xiaoling Fan, Beijing, CN;
Huiyong Xue, Beijing, CN;
Shuang Zhang, Beijing, CN;
Enhong Zhang, Beijing, CN;
Xuying Zhong, Beijing, CN;
Yucheng Lu, Beijing, CN;
Chun Li, Beijing, CN;
Li Song, Beijing, CN;
Abstract
This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.