The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 06, 2011
Filed:
Jul. 20, 2007
Gregory T. Zugates, Cambridge, MA (US);
Andreas Zumbuehl, Bern, CH;
Robert S. Langer, Newton, MA (US);
Daniel G. Anderson, Sudbury, MA (US);
Gregory T. Zugates, Cambridge, MA (US);
Andreas Zumbuehl, Bern, CH;
Robert S. Langer, Newton, MA (US);
Daniel G. Anderson, Sudbury, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.