The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Jul. 01, 2008
Michael E. Llewellyn, Palo Alto, CA (US);
Robert J. Barretto, Menlo Park, CA (US);
Scott L. Delp, Stanford, CA (US);
Mark J. Schnitzer, Palo Alto, CA (US);
Michael E. Llewellyn, Palo Alto, CA (US);
Robert J. Barretto, Menlo Park, CA (US);
Scott L. Delp, Stanford, CA (US);
Mark J. Schnitzer, Palo Alto, CA (US);
The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA (US);
Abstract
Biological thick tissue such as skeletal and cardiac muscle is imaged by inserting a probe into the tissue and scanning the tissue at a sufficiently fast rate to mitigate motion artifacts due to physiological motion. According to one example embodiment, such a probe is part of a system that is capable of reverse-direction high-resolution imaging without staining or otherwise introducing a foreign element used to generate or otherwise increase the sensed light. The probe includes a light generator for generating light pulses that are directed towards structures located within the thick tissue. The light pulses interact with intrinsic characteristics of the structures to generate a signal such as SHG or intrinsic fluorescence. Reliance on intrinsic characteristics of the structures is particularly useful for applications in which the introduction of foreign substances to the thick tissue is undesirable.