The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Jan. 18, 2007
Benzenesulfonyl-chromane, thiochromane, tetrahydronaphthalene and related gamma secretase inhibitors
Theodros Asberom, West Orange, NJ (US);
Thomas A. Bara, Linden, NJ (US);
Chad E. Bennett, Metuchen, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Mary Ann Caplen, Sayreville, NJ (US);
John W. Clader, Cranford, NJ (US);
David J. Cole, Springfield, NJ (US);
Martin S. Domalski, Verona, NJ (US);
Hubert B. Josien, Jersey City, NJ (US);
Chad E. Knutson, Garwood, NJ (US);
Hongmei LI, Warren, NJ (US);
Mark D. Mcbriar, Clinton, NJ (US);
Dmitri A. Pissarnitski, Scotch Plains, NJ (US);
LI Qiang, Edison, NJ (US);
Murali Rajagopalan, Edison, NJ (US);
Thavalakulamgara K. Sasikumar, Edison, NJ (US);
Jing Su, Scotch Plains, NJ (US);
Haiqun Tang, Belle Mead, NJ (US);
Wen-lian Wu, Edison, NJ (US);
Ruo Xu, Watchung, NJ (US);
Zhiqiang Zhao, Scotch Plains, NJ (US);
Theodros Asberom, West Orange, NJ (US);
Thomas A. Bara, Linden, NJ (US);
Chad E. Bennett, Metuchen, NJ (US);
Duane A. Burnett, Bernardsville, NJ (US);
Mary Ann Caplen, Sayreville, NJ (US);
John W. Clader, Cranford, NJ (US);
David J. Cole, Springfield, NJ (US);
Martin S. Domalski, Verona, NJ (US);
Hubert B. Josien, Jersey City, NJ (US);
Chad E. Knutson, Garwood, NJ (US);
Hongmei Li, Warren, NJ (US);
Mark D. McBriar, Clinton, NJ (US);
Dmitri A. Pissarnitski, Scotch Plains, NJ (US);
Li Qiang, Edison, NJ (US);
Murali Rajagopalan, Edison, NJ (US);
Thavalakulamgara K. Sasikumar, Edison, NJ (US);
Jing Su, Scotch Plains, NJ (US);
Haiqun Tang, Belle Mead, NJ (US);
Wen-Lian Wu, Edison, NJ (US);
Ruo Xu, Watchung, NJ (US);
Zhiqiang Zhao, Scotch Plains, NJ (US);
Schering Corporation, Kenilworth, NJ (US);
Abstract
This invention discloses novel gamma secretase inhibitors of the formula: Rand R, or Rand R, or Rand R, together with the atoms to which they are bound, can form a fused cycloalkyl or fused heterocycloalkyl ring. The cycloalkyl ring or the heterocycloalkyl ring can be optionally substituted with one or more substitutents. One or more compounds of formula (I), or formulations comprising such compounds, may be useful, e.g. in treating Alzheimer's Disease.