The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Jul. 25, 2008
Haitao Wang, Vancouver, CA;
Yong Du, Vancouver, CA;
Rui Zhang, Vancouver, CA;
Jing Xu, Vancouver, CA;
Longbin Liu, West Vancouver, CA;
Haitao Wang, Vancouver, CA;
Yong Du, Vancouver, CA;
Rui Zhang, Vancouver, CA;
Jing Xu, Vancouver, CA;
Longbin Liu, West Vancouver, CA;
Novagen Holding Corporation, George Town, KY;
Abstract
A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.