The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 29, 2011

Filed:

Jan. 06, 2010
Applicants:

Arielle Genevois-borella, Thiais, FR;

Craig H. Miller, Winston-Salem, NC (US);

Inventors:

Arielle Genevois-Borella, Thiais, FR;

Craig H. Miller, Winston-Salem, NC (US);

Assignee:

Targacept, Inc., Winston-Salem, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/351 (2006.01); C07D 401/02 (2006.01);
U.S. Cl.
CPC ...
Abstract

Novel vinylazacycloalkane compounds of Formula (I) are disclosed. The compounds are ligands of various nAChRs. The compounds and their pharmaceutically acceptable salts can be used to prepare pharmaceutical compositions and/or medicaments intended to prevent or treat disorders associated with dysfunction of nAChRs, especially within the central nervous system or the gastrointestinal system. Examples of types of disorders that can be treated include neurodegenerative disorders, including central nervous system disorders such as Alzheimer's disease, cognitive disorders, motor disorders such as Parkinson's disease, drug addiction, behavioral disorders and inflammatory disorders within the gastrointestinal system. The compounds can also serve as analgesics in the treatment of acute, chronic or recurrent pain.


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