The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Jul. 20, 2009
Nalin M. Kumar, Wilmette, IL (US);
Beatrice Yue, Deerfield, IL (US);
Shahid Siddiqui, Wilmette, IL (US);
Asrar B. Malik, Hinsdale, IL (US);
Jose S. Pulido, Rochester, MN (US);
Nalin M. Kumar, Wilmette, IL (US);
Beatrice Yue, Deerfield, IL (US);
Shahid Siddiqui, Wilmette, IL (US);
Asrar B. Malik, Hinsdale, IL (US);
Jose S. Pulido, Rochester, MN (US);
The Broad of Trustees of the University of Illinois, Chicago, IL (US);
Abstract
The present application is directed to siRNA-based silencing of the type II receptor of TGFβ. siRNAs that target this receptor abrogate the receptor protein and transcript, TGFβ-mediated processes such as fibronectin assembly and cell migration also are inhibited and the molecules of the invention are efficacious in reducing the inflammatory response and matrix deposition. These findings show that siRNAs can be successfully delivered both in vitro and in vivo to regulate the TGFβ type II receptor level and modulate wound response. Methods and compositions exploiting the findings of the present invention have a wide-ranging application, extending from treatment of disorders of the eye to other organs and tissues throughout the body.