The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 29, 2011
Filed:
Jun. 13, 2003
Simon L. Goodman, Darmstadt, DE;
Beate Diefenbach, Darmstadt, DE;
Detelv Güssow, London, GB;
Raj Mehta, Sudbury, GB;
Eilish Cullen, London, GB;
Alex Brown, Bucks, GB;
Simon L. Goodman, Darmstadt, DE;
Beate Diefenbach, Darmstadt, DE;
Detelv Güssow, London, GB;
Raj Mehta, Sudbury, GB;
Eilish Cullen, London, GB;
Alex Brown, Bucks, GB;
Merck Patent GmbH, Darmstadt, DE;
Abstract
The invention relates to a novel purified recombinant αβadhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural αβadhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the soluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length αβadhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.