The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8063075 B1

PDF
Full Text
Expired
Date of Patent:
Nov. 22, 2011

Filed:

Jun. 02, 2009
Applicants:

Philippe Jablonski, Steinbrunn-le-Haut, FR;

Kenichi Kawasaki, Fujisawa, JP;

Henner Knust, Rheinfelden, DE;

Anja Limberg, Basel, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Hasane Ratni, Habsheim, FR;

Claus Riemer, Freiburg, DE;

Inventors:

Philippe Jablonski, Steinbrunn-le-Haut, FR;

Kenichi Kawasaki, Fujisawa, JP;

Henner Knust, Rheinfelden, DE;

Anja Limberg, Basel, CH;

Matthias Nettekoven, Grenzach-Wyhlen, DE;

Hasane Ratni, Habsheim, FR;

Claus Riemer, Freiburg, DE;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/40 (2006.01); A61K 31/44 (2006.01); C07D 207/04 (2006.01); C07D 401/06 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention relates to compounds of formula I wherein R, R, R, R', Ar, m, n, and o are as defined herein. The invention also relates to pharmaceutical compositions containing compounds of formula I and methods for the manufacture of such compounds and compositions. Compounds of the invention are high potential NK-3 receptor antagonists for the treatment of depression, pain, psychosis, Parkinson's disease, schizophrenia, anxiety and attention deficit hyperactivity disorder (ADHD).


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