The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2011

Filed:

Sep. 11, 2007
Applicants:

Peter A. Blomgren, North Branford, CT (US);

Kevin S. Currie, North Branford, CT (US);

Jeffrey E. Kropf, Branford, CT (US);

Tony Lee, Branford, CT (US);

James W. Darrow, Wallingford, CT (US);

Scott A. Mitchell, East Haven, CT (US);

Jianjun Xu, Branford, CT (US);

Aaron C. Schmitt, Hamden, CT (US);

Inventors:

Peter A. Blomgren, North Branford, CT (US);

Kevin S. Currie, North Branford, CT (US);

Jeffrey E. Kropf, Branford, CT (US);

Tony Lee, Branford, CT (US);

James W. Darrow, Wallingford, CT (US);

Scott A. Mitchell, East Haven, CT (US);

Jianjun Xu, Branford, CT (US);

Aaron C. Schmitt, Hamden, CT (US);

Assignee:

Gilead Connecticut, Inc., Foster City, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 409/00 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
Abstract

At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical compositions comprising at least one chemical entity of the invention, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.


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