The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 15, 2011

Filed:

Apr. 06, 2010
Applicants:

David L. Berstein, Waban, MA (US);

Leonard W. Rozamus, Bedford, MA (US);

Yihan Wang, Newton, MA (US);

Chester A. Metcalf, Iii, Needham, MA (US);

Inventors:

David L. Berstein, Waban, MA (US);

Leonard W. Rozamus, Bedford, MA (US);

Yihan Wang, Newton, MA (US);

Chester A. Metcalf, III, Needham, MA (US);

Assignee:

ARIAD Pharmaceuticals, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 267/00 (2006.01);
U.S. Cl.
CPC ...
Abstract

This invention concerns a new family of phosphorus-containing compounds containing a moiety JQA- in which: A is absent or is —O—, —S— or —NR—; Q is absent or (if A is —O—, —S— or —NR—) Q may be —V—, —OV—, —SV—, or —NRV—, where V is an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, such that J is linked to the cyclohexyl ring directly, through A or through VA, OVA, SVA or NRVA; K is O or S;each occurrence of Y is independently —O—, —S—, —NR—, or a bond linking a Rmoiety to P;each occurrence of Rand Ris independently an aliphatic, heteroaliphatic, aryl, or heteroaryl moiety, or H; andeach occurrence of Ris independently —PK(YR)(YR), —SO(YR) or —C(O)(YR); so long as any R, or Rmoiety linked directly to P is not H;wherein two R, Rand/or Rmoieties may be chemically linked to one another to form a ring;each occurrence of G is independently —O—, —S—, —NR— or (M);each occurrence of M is independently a substituted or unsubstituted methylene moiety, and any M-M' moiety may be saturated or unsaturated;each occurrence of x is independently an integer from 1-6; and the other variables are as defined herein.


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