The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2011
Filed:
Mar. 28, 2007
Yasuhiro Kajihara, Yokohama, JP;
Naoki Yamamoto, Tokushima, JP;
Yuri Nambu, Tokushima, JP;
Kazuhiro Fukae, Tokushima, JP;
Hiroaki Asai, Tokushima, JP;
Yasuhiro Kajihara, Yokohama, JP;
Naoki Yamamoto, Tokushima, JP;
Yuri Nambu, Tokushima, JP;
Kazuhiro Fukae, Tokushima, JP;
Hiroaki Asai, Tokushima, JP;
Otsuka Chemical Co., Ltd., Osaka-shi, JP;
Abstract
The present invention provides a process for producing a peptide thioester compound. The process involves: (A) forming a peptide by a solid-phase synthesis method using a resin modified with a linker represented by the formula (1) as a solid phase: wherein Rrepresents Calkyl group, Rrepresents hydrogen atom or Calkoxy group, and n represents an integer of 1 to 4; (B) cleaving a bond between the solid phase and the peptide with at least one acid selected from dilute hydrochloric acid, dilute sulfuric acid, formic acid, and acetic acid to produce a peptide having a carboxyl group at the C-terminus; and (C) reacting a thiol compound with the peptide at −100 to 0° C. in the presence of a condensing agent in a solvent.