IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8058284 B1

PDFFull Text
Date of Patent:
Nov. 15, 2011

Filed:

Nov. 03, 2006

[4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto

Applicants:

Robert Scarborough, Half Moon Bay, CA (US);

Carroll Anna Scarborough, Legal Representative, Half Moon Bay, CA (US);

Wolin Huang, Foster City, CA (US);

Mukund Mehrotra, South San Francisco, CA (US);

Xiaoming Zhang, Sunnyvale, CA (US);

Hilary Cannon, Hertfordshire, GB;

Craig M. Grant, Burwell, GB;

Inventors:

Robert Scarborough, Half Moon Bay, CA (US);

Carroll Anna Scarborough, legal representative, Half Moon Bay, CA (US);

Wolin Huang, Foster City, CA (US);

Mukund Mehrotra, South San Francisco, CA (US);

Xiaoming Zhang, Sunnyvale, CA (US);

Hilary Cannon, Hertfordshire, GB;

Craig M. Grant, Burwell, GB;

Assignee:

Portola Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorney:

Kilpatrick Townsend and Stockton LLP

Primary Examiner:

Emily Bernhardt

Int. Cl.
CPC ...
A61K 31/517 (2006.01); C07D 409/12 (2006.01);
U.S. Cl.
CPC ...
Abstract

The present invention provides novel sulfonylurea compounds of formula (I) and pharmaceutically acceptable derivatives and polymorph and amorphous forms thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides a method for preparing such compounds and forms and for preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or forms thereof.

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