The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2011
Filed:
Nov. 09, 2009
Silvano Fumero, Ivrea, IT;
Luisa Bertarione Rava Rossa, Pavone Canaverse, IT;
Domenico G. Barone, Turin, IT;
Lila Drittanti, Vigneux sur Siene, FR;
Thierry Guyon, Palaiseau, FR;
Gilles Borrelly, Epinay sous Senart, FR;
Barbara Canepa, San Sebastiano da Po, IT;
Chiara Lorenzetto, Villafranca Piemonte, IT;
Silvano Fumero, Ivrea, IT;
Luisa Bertarione Rava Rossa, Pavone Canaverse, IT;
Domenico G. Barone, Turin, IT;
Lila Drittanti, Vigneux sur Siene, FR;
Thierry Guyon, Palaiseau, FR;
Gilles Borrelly, Epinay sous Senart, FR;
Barbara Canepa, San Sebastiano da Po, IT;
Chiara Lorenzetto, Villafranca Piemonte, IT;
Creabilis Therapeutics S.p.A., Colleretto Giacosa, IT;
Abstract
The present invention relates to polypeptide variants of the HMGB-1 high affinity binding domain Box-A (HMGB1 Box-A) or to a biologically active fragment of HMGB1 Box-A, which are obtained through systematic mutations of single amino acids of the wild-type HMGB1 Box-A protein and which show an increased resistance to proteases and which are therefore characterized by more favorable pharmacokinetic and pharmacodynamic profiles. Moreover, the present invention concerns the use of said polypeptide molecules of HMGB1 Box-A to diagnose, prevent, alleviate and/or treat pathologies associated with extracellular HMGB1 and associated with RAGE.