The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 2011
Filed:
Mar. 27, 2008
Andreas Boettcher, Basel, CH;
Nicole Buschmann, Basel, CH;
Pascal Furet, Basel, CH;
Jean-marc Groell, Basel, CH;
Jorg Kallen, Basel, CH;
Joanna Hergovich Lisztwan, Basel, CH;
Keiichi Masuya, Basel, CH;
Lorenz Mayr, Basel, CH;
Andrea Vaupel, Basel, CH;
Andreas Boettcher, Basel, CH;
Nicole Buschmann, Basel, CH;
Pascal Furet, Basel, CH;
Jean-Marc Groell, Basel, CH;
Jorg Kallen, Basel, CH;
Joanna Hergovich Lisztwan, Basel, CH;
Keiichi Masuya, Basel, CH;
Lorenz Mayr, Basel, CH;
Andrea Vaupel, Basel, CH;
Novartis AG, Basel, CH;
Abstract
The invention relates to 3-heterocyclyl indolyl compounds of formula I capable of inhibiting the interaction between p53, or variants thereof, and MDM2 and/or MDM4, or variants thereof, respectively: wherein R, R, R, R, R, Y and Y are as defined in the specification. Due to their activity, the compounds are useful in the treatment of various disorders and diseases mediated by the activity of MDM2 and/or MDM4, or variants thereof, such as inflammatory or proliferative diseases or in the protection of cells.