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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8053439 B1

PDFFull Text
Date of Patent:
Nov. 08, 2011

Filed:

Sep. 21, 2007

Benzophenone derivatives useful for inhibiting formation of microtubule

Applicants:

Nam-song Choi, Cheonan-si, KR;

Young-mi Kim, Cheonan-si, KR;

Young-hoon Kim, Yongin-si, KR;

Jae-kwang Lee, Cheonan-si, KR;

In-taek Lim, Cheonan-si, KR;

Ho-jin Choi, Hwaseong-si, KR;

Hyun-mo Yang, Cheonan-si, KR;

Seung-kee Moon, Cheonan-si, KR;

Soo-jin Kim, Cheonan-si, KR;

Hyun-jung Yu, Cheonan-si, KR;

Jae-su Shin, Seoul, KR;

Young-min Kwon, Goyang-si, KR;

Sung-sook Lee, Cheonan-si, KR;

Soon-kil Ahn, Seoul, KR;

Sun-ju Kong, Cheonan-si, KR;

Inventors:

Nam-Song Choi, Cheonan-si, KR;

Young-Mi Kim, Cheonan-si, KR;

Young-Hoon Kim, Yongin-si, KR;

Jae-Kwang Lee, Cheonan-si, KR;

In-Taek Lim, Cheonan-si, KR;

Ho-Jin Choi, Hwaseong-si, KR;

Hyun-Mo Yang, Cheonan-si, KR;

Seung-Kee Moon, Cheonan-si, KR;

Soo-Jin Kim, Cheonan-si, KR;

Hyun-Jung Yu, Cheonan-si, KR;

Jae-Su Shin, Seoul, KR;

Young-Min Kwon, Goyang-si, KR;

Sung-Sook Lee, Cheonan-si, KR;

Soon-Kil Ahn, Seoul, KR;

Sun-Ju Kong, Cheonan-si, KR;

Assignee:

Chong Kun Dang Pharmaceutical Corp., Seoul, KR;

Attorney:

Lucas & Mercanti, LLP

Primary Examiner:

Yong Chu

Assistant Examiner:

Michael Barker

Int. Cl.
CPC ...
A61K 31/341 (2006.01); A61K 31/381 (2006.01); A61K 31/40 (2006.01); A61K 31/415 (2006.01); A61K 31/4164 (2006.01); A61K 31/4196 (2006.01); A61K 31/421 (2006.01); A61K 31/426 (2006.01); A61K 31/4418 (2006.01); A61K 31/454 (2006.01); A61K 31/505 (2006.01); A61K 31/12 (2006.01); C07C 49/786 (2006.01); C07D 307/46 (2006.01); C07D 333/22 (2006.01); C07D 207/333 (2006.01); C07D 231/12 (2006.01); C07D 233/64 (2006.01); C07D 277/24 (2006.01); C07D 263/32 (2006.01); C07D 231/46 (2006.01); C07D 239/26 (2006.01);
U.S. Cl.
CPC ...
Abstract

Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.

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