The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2011
Filed:
Nov. 15, 2010
Bruce Decosta, Salem, NH (US);
Francis G. Fang, Andover, MA (US);
James E. Foy, Andover, MA (US);
Lynn Hawkins, Concord, MA (US);
Charles Lemelin, North Chelmsford, MA (US);
Xiang Niu, Watertown, MA (US);
Kuo-ming Wu, Acton, MA (US);
Bruce DeCosta, Salem, NH (US);
Francis G. Fang, Andover, MA (US);
James E. Foy, Andover, MA (US);
Lynn Hawkins, Concord, MA (US);
Charles Lemelin, North Chelmsford, MA (US);
Xiang Niu, Watertown, MA (US);
Kuo-Ming Wu, Acton, MA (US);
Eisai R&D Management Co., Ltd., Tokyo, JP;
Abstract
This invention relates to the synthesis for a precursor of E6020, compound 26, via a β-keto amide alcohol intermediate, compound 22. The synthesis reacts compound 22 with compound 25 and the resultant intermediate is oxidized to produce compound 26, the precursor to E6020. Compounds 22 and 25, and their crystalline forms, represent separate embodiments of the invention. The invention also relates to compounds of formulas (3) and (4) and processes for their preparation. The β-keto amide alcohol intermediate compound 22 is a compound of formula (3). Compound 25 is a compound of formula (4).