5- [4-(azetidin-3-yloxy)-phenyl]-2-phenyl-5h-thiazolo[5,4-c] pyridin-4-one derivatives and their use as mch receptor antagonists

Abstract

The present invention relates to a melanin concentrating hormone antagonist compound of formula I: wherein '-----' is absent or is optionally a bond; q is 1 or 2; Ris independently selected from hydrogen, —C-Calkyl, halo, hydroxy, —C-Chaloalkyl, —C-Calkoxy, cyano, —O—C-Ccycloalkyl, and —OC-Chaloalkyl; Ris selected from the group consisting of hydrogen, —C-Calkyl, hydroxy, —C-Calkoxy, cyano, —C-Chaloalkyl, —OC-Chaloalkyl, and halo; Ris selected from the group consisting of hydrogen, —C-Calkyl, —C-Chaloalkyl, —C-CalkylOH, —C-Ccycloalkyl, —CHC-Ccycloalkyl, —C-Calkyl-O—C-Calkyl, —C(O)C-Calkyl, —C(O)C-Chaloalkyl, —CH-thiazole, phenyl, benzyl, tetrahydrothiopyranyl, and tetrahydropyranyl, wherein the cycloalkyl, tetrahydrothiopyranyl, tetrahydropyranyl and thiazolyl group is optionally substituted with one or two groups independently selected from the group consisting of halo, hydroxy, C-Calkyl, and —C-Chaloalkyl; or a pharmaceutically acceptable salt, enantiomer, diastereomer or mixture thereof, useful in the treating, preventing or ameliorating of symptoms associated with obesity and related diseases.