The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2011
Filed:
Aug. 30, 2010
Keizo Koya, Chestnut Hill, MA (US);
Lijun Sun, Harvard, MA (US);
Elena Kostik, Arlington, MA (US);
Farid Vaghefi, Watertown, MA (US);
Shoujun Chen, Bedford, MA (US);
Noriaki Tatsuta, Lexington, MA (US);
Guiqing Liang, Concord, MA (US);
Takayo Inoue, Malden, MA (US);
Zhi-qiang Xia, Acton, MA (US);
Keizo Koya, Chestnut Hill, MA (US);
Lijun Sun, Harvard, MA (US);
Elena Kostik, Arlington, MA (US);
Farid Vaghefi, Watertown, MA (US);
Shoujun Chen, Bedford, MA (US);
Noriaki Tatsuta, Lexington, MA (US);
Guiqing Liang, Concord, MA (US);
Takayo Inoue, Malden, MA (US);
Zhi-Qiang Xia, Acton, MA (US);
Synta Pharmaceuticals Corp., Lexington, MA (US);
Abstract
Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I): Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R-Rare independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, and/or Rand Rtaken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is —O or —S. Mis a pharmaceutically acceptable monovalent cation and Mis a pharmaceutically acceptable divalent cation. Also, disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt described above.