The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2011
Filed:
Nov. 16, 2004
Kompella Amala, Hyderabad, IN;
Thungathurthi Srinivasa Rao, Hyderabad, IN;
Bhujanga Rao Adibhatla Kali Satya, Hyderabad, IN;
Sreenivas Rachakonda, Hyderabad, IN;
Nannapaneni Venkaiah Chowdary, Hyderabad, IN;
Khadgapathi Podili, Hyderabad, IN;
Kompella Amala, Hyderabad, IN;
Thungathurthi Srinivasa Rao, Hyderabad, IN;
Bhujanga rao Adibhatla Kali Satya, Hyderabad, IN;
Sreenivas Rachakonda, Hyderabad, IN;
Nannapaneni Venkaiah Chowdary, Hyderabad, IN;
Khadgapathi Podili, Hyderabad, IN;
Natco Pharma Limited, Hyderabad, IN;
Abstract
This invention discloses a novel stable crystal form of imatinib mesylate, designated by us as αForm, which is stable at room temperature and even at higher temperatures up to 120° C. and accelerated stress conditions and, freely soluble in water. This invention also discloses a pharmaceutical composition containing the novel stable αform of Imatinib mesylate and other usually employed excipients, useful in the treatment of Chronic Myelogenous Leukemia (CML). This new αForm of imatinib mesylate is prepared by slurrying Imatinib base in isopropanol at room temperature followed by addition of methane sulfonic acid and maintaining 50-60 ° C. followed by filtration. This invention also discloses another process for the preparation of the novel, stable αcrystalline form of Imatinib Mesylate by the conversion of Imatinib mesylate β-polymorphic modification by suspending it in water and organic solvents, distilling off water azeotropically, cooling and filtering to obtain the αcrystal form.