The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 01, 2011
Filed:
Jul. 31, 2009
Oskar Zelder, Speyer, DE;
Corinna Klopprogge, Mannheim, DE;
Hartwig Schroder, Nussloch, DE;
Stefan Haefner, Ludwigshafen, DE;
Burkhard Kröger, Limburgerhof, DE;
Patrick Kiefer, Zurich, DE;
Elmar Heinzle, Saarbrücken, DE;
Christoph Wittmann, Saarbrücken, DE;
Oskar Zelder, Speyer, DE;
Corinna Klopprogge, Mannheim, DE;
Hartwig Schroder, Nussloch, DE;
Stefan Haefner, Ludwigshafen, DE;
Burkhard Kröger, Limburgerhof, DE;
Patrick Kiefer, Zurich, DE;
Elmar Heinzle, Saarbrücken, DE;
Christoph Wittmann, Saarbrücken, DE;
BASF SE, , DE;
Abstract
The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine inby way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.