The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2011
Filed:
Apr. 18, 2003
David J. Ecker, Encinitas, CA (US);
Richard H. Griffey, Vista, CA (US);
Rangarajan Sampath, San Diego, CA (US);
Steven A. Hofstadler, Oceanside, CA (US);
John Mcneil, La Jolla, CA (US);
Stanley T. Crooke, Carlsbad, CA (US);
Dino J. Sofianos, San Diego, CA (US);
Karl H. Rudnick, Solana Beach, CA (US);
Duane J. Knize, La Jolla, CA (US);
Roland B. Stoughton, San Diego, CA (US);
Cecil L. Basham, Jr., Del Mar, CA (US);
Clifford T. Lewis, San Diego, CA (US);
Brons M. Larson, Santee, CA (US);
Jonathan R. Bar-on, San Diego, CA (US);
Dennis P. Murray, Culver City, CA (US);
David W. Robbins, San Diego, CA (US);
John P. Penhune, La Jolla, CA (US);
David J. Ecker, Encinitas, CA (US);
Richard H. Griffey, Vista, CA (US);
Rangarajan Sampath, San Diego, CA (US);
Steven A. Hofstadler, Oceanside, CA (US);
John McNeil, La Jolla, CA (US);
Stanley T. Crooke, Carlsbad, CA (US);
Dino J. Sofianos, San Diego, CA (US);
Karl H. Rudnick, Solana Beach, CA (US);
Duane J. Knize, La Jolla, CA (US);
Roland B. Stoughton, San Diego, CA (US);
Cecil L. Basham, Jr., Del Mar, CA (US);
Clifford T. Lewis, San Diego, CA (US);
Brons M. Larson, Santee, CA (US);
Jonathan R. Bar-on, San Diego, CA (US);
Dennis P. Murray, Culver City, CA (US);
David W. Robbins, San Diego, CA (US);
John P. Penhune, La Jolla, CA (US);
Ibis Biosciences, Inc., Carlsbad, CA (US);
Abstract
Rapid and definitive bioagent detection and identification can be carried out without nucleic acid sequencing. Analysis of a variety of bioagents and samples, such as air, fluid, and body samples, can be carried out to provide information useful for industrial, medical, and environmental purposes. Nucleic acid samples of unknown or suspected bioagents may be collected, optimal primer pairs may be selected, and the nucleic acid may be amplified. Expected mass spectra signal models may be generated and selected, the actual mass spectra of the amplicons may be obtained. The expected mass spectra most closely correlating with the actual mass spectra may be determined using a joint maximum likelihood analysis, and base counts for the actual mass spectra and the expected mass spectra may be obtained. The most likely candidate bioagents may then be determined.