The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2011
Filed:
Jul. 13, 2009
Sean Stevens, Mohegan Lake, NY (US);
Tammy T. Huang, Golden Bridge, NY (US);
Joel H. Martin, Putnam Valley, NY (US);
Jeanette L. Fairhurst, White Plains, NY (US);
Ashique Rafique, Yonkers, NY (US);
Eric Smith, New York, NY (US);
Kevin J. Pobursky, Beacon, NY (US);
Nicholas J. Papadopoulos, LaGrangeville, NY (US);
James P. Fandl, LaGrangeville, NY (US);
Gang Chen, Yorktown Heights, NY (US);
Margaret Karow, Camarillo, CA (US);
Sean Stevens, Mohegan Lake, NY (US);
Tammy T. Huang, Golden Bridge, NY (US);
Joel H. Martin, Putnam Valley, NY (US);
Jeanette L. Fairhurst, White Plains, NY (US);
Ashique Rafique, Yonkers, NY (US);
Eric Smith, New York, NY (US);
Kevin J. Pobursky, Beacon, NY (US);
Nicholas J. Papadopoulos, LaGrangeville, NY (US);
James P. Fandl, LaGrangeville, NY (US);
Gang Chen, Yorktown Heights, NY (US);
Margaret Karow, Camarillo, CA (US);
Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US);
Abstract
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a Kof about 500 pM or less and blocks IL-6 activity with an ICof 200 pM or less. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.