The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2011
Filed:
Sep. 29, 2006
Ogari Pacheco, Itapira, BR;
Antonio Carlos Teixeira, Itapira, BR;
Edson Luiz Lima, Itapira, BR;
Maria Alice Böckelmann, Itapira, BR;
Ogari Pacheco, Itapira, BR;
Antonio Carlos Teixeira, Itapira, BR;
Edson Luiz Lima, Itapira, BR;
Maria Alice Böckelmann, Itapira, BR;
Cristalia Produtos Quimicos Farmaceuticos Ltda., Itapira, BR;
Abstract
The present invention refers to a process for the preparation of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl) ethyl ether (sevochlorane), which consists of reacting hexafluoroisopropanol with: a formaldehyde equivalent selected between paraformaldehyde or 1,3,5-trioxane, a chlorinating agent selected from the group consisting of oxalyl chloride, phosphorus trichloride, phosphorus pentachloride, phosphorus oxychloride, sulfuryl chloride and thionyl chloride, and a strong acid selected from the group consisting of concentrated or fuming sulfuric acid. Said process provides sevochlorane in high purity and yield, which can be converted to sevoflurane by known means.