The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2011
Filed:
Feb. 04, 2009
Steven Lee Bender, Oceanside, CA (US);
Gerald Fries Casperson, Ballwin, MO (US);
Dana Dan Hu-lowe, Encinitas, CA (US);
Xin Jiang, San Diego, CA (US);
Gang LI, San Diego, CA (US);
Michael Aidan North, Rancho Santa Fe, CA (US);
Jianying Wang, San Diego, CA (US);
Grant Wickman, Glasgow, GB;
Peter Brams, Sacramento, CA (US);
Haichun Huang, Fremont, CA (US);
Brigitte Devaux, Palo Alto, CA (US);
Haibin Chen, Sunnyvale, CA (US);
Dawn M. Tanamachi, Milpitas, CA (US);
Kristopher Toy, San Jose, CA (US);
Lan Yang, Morgan Hill, CA (US);
Tim W. Sproul, Livermore, CA (US);
Mark Yamanaka, Pleasanton, CA (US);
Steven Lee Bender, Oceanside, CA (US);
Gerald Fries Casperson, Ballwin, MO (US);
Dana Dan Hu-Lowe, Encinitas, CA (US);
Xin Jiang, San Diego, CA (US);
Gang Li, San Diego, CA (US);
Michael Aidan North, Rancho Santa Fe, CA (US);
Jianying Wang, San Diego, CA (US);
Grant Wickman, Glasgow, GB;
Peter Brams, Sacramento, CA (US);
Haichun Huang, Fremont, CA (US);
Brigitte Devaux, Palo Alto, CA (US);
Haibin Chen, Sunnyvale, CA (US);
Dawn M. Tanamachi, Milpitas, CA (US);
Kristopher Toy, San Jose, CA (US);
Lan Yang, Morgan Hill, CA (US);
Tim W. Sproul, Livermore, CA (US);
Mark Yamanaka, Pleasanton, CA (US);
Bristol-Myers Squibb Company, Princeton, NJ (US);
Pfizer Inc., New York, NY (US);
Abstract
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin α5β1 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-α5β1 antibodies or antigen binding portions thereof described herein.