The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 18, 2011
Filed:
Apr. 16, 2009
Yen-tung Luan, Chelmsford, MA (US);
Wenge Wang, North Chelmsford, MA (US);
Gregg Nyberg, Westminster, CO (US);
Jose Manuel Gomes, Chelmsford, MA (US);
Denis Drapeau, Salem, NH (US);
Terry Cardoza, Methuen, MA (US);
Yen-Tung Luan, Chelmsford, MA (US);
Wenge Wang, North Chelmsford, MA (US);
Gregg Nyberg, Westminster, CO (US);
Jose Manuel Gomes, Chelmsford, MA (US);
Denis Drapeau, Salem, NH (US);
Terry Cardoza, Methuen, MA (US);
Wyeth LLC, Madison, NJ (US);
Abstract
Methods and processes for improved recombinant protein production are provided. The methods are useful for production of growth factors, particularly those of the TGF-β superfamily, including bone morphogenetic proteins (BMPs), such as BMP-2. Suitable host cells are cultured in media where iron is present at a concentration of at least 2.25 μM and if pyridoxal is present, it makes up less than 55% of the molar concentration of vitamin B6 in the media.